Schlagwort-Archive: differentiation

Calcium gradient in skin, vitamin D and filaggrin

As filaggrin – one of our best atopy genes – is vitamin D dependent, I tried to find out more about epidermal differentiation. The plot here summarizes an earlier review:
cagradient.png
There seems to be a clear calcium gradient with the expression of differentiation specific marker in the single strata. So there is some good chance that filaggrin effects may be modified by external vitamin D supply.