There are news about the hygiene hypothesis.
Home cleanliness resulted only in quantitative reduction of floor dust, which mainly indicates removal of superficial dirt with a rather cosmetic effect. Conventional cleaning does not eradicate microorganisms sustainably, because emptied microbial niches are instantly recolonized by ventilation and living carrier.
Sure. Continue reading Is this a retraction of the hygiene hypothesis?
As filaggrin – one of our best atopy genes – is vitamin D dependent, I tried to find out more about epidermal differentiation. The plot here summarizes an earlier review:
There seems to be a clear calcium gradient with the expression of differentiation specific marker in the single strata. So there is some good chance that filaggrin effects may be modified by external vitamin D supply.