Tag Archives: pain

Rejection hurts. Why everybody needs somebody

515 citations of an article in 5 years – it is timely to revisit “Does Rejection Hurt? An fMRI Study of Social Exclusion” by Eisenberger in Science magazine. I was refered to that study by “Lob der Schule” (an excellent book).

Participants were scanned while playing a virtual ball-tossing game in which they were ultimately excluded. Paralleling results from physical pain studies, the anterior cingulate cortex (ACC) was more active during exclusion.

These are bad news for all victims of workplace bullying or university harassment – their brains will react like under stimulation of physical harm leading to aggression as found in many studies

A wide variety of studies with animal as well as human subjects demonstrate that pain often gives rise to an inclination to hurt an available target, and also, at the human level, that people in pain are apt to be angry.

So, the final aggression of the victim is used to further isolate it – a vicious circle.

Rolling Stones

Blues Brothers

10.1.2019 revisited

The facts seem to be now largely accepted, see an article in Psychology Today: Is Social Pain Real Pain? and the 2012 review by Eisenberger. More recently some authors even think that “The salience of self, not social pain, is encoded by dorsal anterior cingulate and insula“.


A tragedy if you don’t feel pain

A highly successfull study of the molecular pathways of nociception (and identification of a loss of function mutation in the alpha subunit of SCN9A, a voltage gated sodium channel) has a sad story from Northern Pakistan

The index case for the present study was a ten-year-old child, well known to the medical service after regularly performing ‘street theatre’. He placed knives through his arms and walked on burning coals, but experienced no pain. He died before being seen on his fourteenth birthday, after jumping off a house roof.

It is so difficult for us humans to accept that pain has an important function in life, yea, yea.