This is an update of the recent TCRA post herewhere I argued that TCR studies shouldn’t be done with genomic DNA from peripheral blood cells. Instead, I was arguing for buccal DNA as epithelial cells will not have undergone somatic recombination. Only last week, however, I came across an earlier letter about DNA-based assessment of chimerism after allogeneic blood stem cell transplantation (BSCT). Continue reading Is buccal DNA really buccal DNA?
Tag Archives: sequencing
Forget about genes V
Life after GWAS comments
Allen Roses, director of the Deane Drug Discovery Institute at Duke University, noted that GWAS has “largely disappointed its most enthusiastic proponents Continue reading Forget about genes V
Illumina 1G Solexa roadshow
I attended today a seminar organized by Illumina here at Mariott in Munich covering their new sequencing technology after the recent acquistion of Solexa. Maybe it is easy to impress me but it seems that also the rest of the audience shared my amazement. Continue reading Illumina 1G Solexa roadshow
3,93 mutations / Mb
1 MB is 1 Megabyte is 1,000,000 bytes and 1 Mb is 1 Megabase is 1,000,000 nucleotides. Although a new nature paper doesn’t make any fuss about it, there are 3,93 mutations / Mb in cancer tissues (in total they found 1,007 mutations by scanning 274 Mb from 210 cancer tissues). Continue reading 3,93 mutations / Mb