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Allergy, Genetics, Vitamins

ORMDL3 graduated

Given my sceptical view that ORMDL3 is really an asthma gene (that may be even shared by the authors of the initial association) the train has now departed with more groups speculating about ORMDL3 function.
For example this new paper by Gerard Cantero-Recasens is about the unfolded protein response (UPR) that may be triggered by a putative loss of function mutation in ORMDL3 via a Ca2+ decrease in the ER. Although I am quite intrigued about the fact that the story now moves to calcium and vitamin D, we are far away from any conclusive evidence.

Addenddum 3.3.2010

And here is another paper that associates ORMDL3 to the sphingolipid metabolism. Although that may be also an interesting pathway (given a bulk of literature not cited in the paper ( more, more, more, more) I still wonder if this is wishful thinking. The authors do not touch the main problem – the weak connection of some genomic variants in that region to ORMDL3 function to asthma pathogenesis.

 

CC-BY-NC Science Surf , accessed 24.03.2026
Software

SQLite and a graphical ER diagrammer for OS X

I am looking for some time for a MS-Acess like graphical interface addressing my large SQLite databases. Having tried out now more than dozen different packages, I found only one that fills my needs and even that only by 80% – RazorSQL.
Writing complex SQL queries is possible hwith an “autocomplete” function Continue reading SQLite and a graphical ER diagrammer for OS X →

 

CC-BY-NC Science Surf , accessed 24.03.2026
Allergy, Vitamins

Tired of the hygiene hypothesis

A new Thorax review finds

The hypotheses have arisen from a desire to explain epidemiological differences, and those such as the “hygiene” hypothesis had a seemingly corroboratory immunological explanation. However, they have not taken us to the point where we can proudly announce a primary preventive strategy.

I agree with the last statement but have severe doubts on any “immunological explanation” Continue reading Tired of the hygiene hypothesis →

 

CC-BY-NC Science Surf , accessed 24.03.2026
Software

The art of a clean Mac OS X desktop

I spent considerable time this week as my MBA showed major quirks – the finder’s trashcan did not respond, clicking on the finder in the dock suddenly opened a second icon, while the finder crashed frequently. Running harddisk maintenance, correcting access rights, deleting several plists, experimenting with safe mode, even deleting PRAM and NVRAM – nothing helped until Continue reading The art of a clean Mac OS X desktop →

 

CC-BY-NC Science Surf , accessed 24.03.2026
Theology

Tobe, Welt und springe

Bach cantatas are at a nice page of cs.ualberta.ca incuding my favorite BWV 227

Trotz dem alten Drachen,
Trotz des Todes Rachen,
Trotz der Furcht darzu!
Tobe, Welt, und springe,
Ich steh hier und singe
In gar sichrer Ruh.
Gottes Macht hält mich in acht;
Erd und Abgrund muss verstummen,
Ob sie noch so brummen.

 

CC-BY-NC Science Surf , accessed 24.03.2026
Genetics, Philosophy, Theology

Unscientific World

A review of “Unscientific America” on p 678 in Science Magazine 7 Aug 2009 finds

According to Mooney and Kirshenbaum, atheistic scientists such as Richard Dawkins and P. Z. Myers [who runs the immensely popular science blog Pharyngula] drive people away from science by forcing them to choose between the facts and their faith.

 

CC-BY-NC Science Surf , accessed 24.03.2026
Genetics, Philosophy, Theology

evo-devo-dis

I am curently working on a new lecture series on that topic – having a gut feeling that the evolutionary history will explain how and why we get diseases. Some German magazines (“Fehlkonstruktion Mensch” DER SPIEGEL 40/2009) even write about that topic quoting a forthcoming book of Ganten / Deichmann / Spahl). I will rely, however, mostly on Continue reading evo-devo-dis →

 

CC-BY-NC Science Surf , accessed 24.03.2026