Category Archives: Allergy

Allergy, Genetics

Blink Plink

I had the chance to install now the new PLINK GWAS software for a further analysis of recently published ORMDL3 asthma data. It seems that PLINK is some software that I was looking for a long time (paper link|download link). There are great and foolproof functions to check the validity of your data. I discovered for example unnoticed stratification in the German case-control sample by first and second component of the MDS analysis Continue reading Blink Plink →

 

CC-BY-NC Science Surf 13.08.2007, access 16.10.2025
Allergy

Allergy transplantation

A new paper in Transplantation takes up an old question – can you passively transfer asthma or allergy? It seems so – the current study reports in 5 of 42 patients elevated IgE plus allergy symptoms. This is in line with earlier reports. Sorry to say — you can get allergy also by bone marrow transplantation.

 

Addendum 10/6/08
Blood

A total of 16 nonallergic recipients with allergic donors were reported to develop allergic disease posttransplant, however, conclusive information was available for only 5 cases. Allergic disease was reported to abate in 3 allergic recipients with nonallergic donors, however, conclusive information was available for only 2 cases. Problems in interpreting the reports include incomplete data on allergic disease in the donor or recipient pretransplant, not knowing the denominator, and the lack of controls. In summary, review of the literature generates the hypothesis that allergic disease is transferable

 

Addendum 14/7/22
Ann All Asthma Immunol

 

CC-BY-NC Science Surf 3.08.2007, access 16.10.2025
Allergy, Joke

Allergy – everything from fullerenes to cannabis

Allergy research continues to be one of the most active research fields. New studies show that that fullerenes may inhibit the allergic response

Human MC and peripheral blood basophils exhibited a significant inhibition of IgE dependent mediator release when preincubated with C60 fullerenes.

Continue reading Allergy – everything from fullerenes to cannabis →

 

CC-BY-NC Science Surf 22.06.2007, access 16.10.2025
Allergy, Genetics, Philosophy

The third largest problem in epidemiology

-moblog- In my view, epidemiology is not very flexible to adjust to new methods and new techniques. Following some discussion that I had today with STW about eQTLs (quantitative traits derived by RNA microarrays or metabolome profiles) and JMA about system biology, it is likely that we are facing huge changes. Phenotypes may no more called intermediary and we may soon forget old controversies of disease definition. We will instead use new system-terms like NonImm076Trig31Ste0098 or TLR9-096321-Auto5337. Yea, yea.

 

CC-BY-NC Science Surf 22.05.2007, access 16.10.2025
Allergy, Genetics

Lactase variants in Europe – any connection to allergy?

I will present this poster next Monday in San Francisco at the Annual Conference of the American Thoracic Society. Continue reading Lactase variants in Europe – any connection to allergy? →

 

CC-BY-NC Science Surf 17.05.2007, access 16.10.2025
Allergy, Vitamins

Osteopontin bridging air pollution and immunology of allergic inflammation

Ostepopontin (OPN) is a remarkable substance. The many aliases already point towards a multitude of biological functions: SPP1=secreted phosphoprotein 1, BSPI 1=bone sialoprotein-1, CIT, ETA-1, GC110940, nephropontin, osteoprotegerin, uropontin, bone sialoprotein I, early T-lymphocyte activation among others. Continue reading Osteopontin bridging air pollution and immunology of allergic inflammation →

 

CC-BY-NC Science Surf 9.05.2007, access 16.10.2025