X chromosomal inactivation is difficult enough to understand – there are now some more data on autosomal monoallelic expression (editorial & paper). Up to 10% of 4,000 genes in clonal cell lines were found to be monoallelic expressed (and up to 20% in some B cell clones). Only odorant and T cell receptors are selectively expressed while all other genes are thought to be randomly silenced.
I wonder how any transmission disequilibrium test makes sense if a variant is only transmitted to a silent chromosome? Possibly there are also epigenetic feedback loops where proteins can remodel chromatin and induce epigenetic marks ultimately silencing a chromosomal region. In any case, a fundamental paper, yea, yea!

isn´t my second paper as this NEJM letter was sent out without me. Authorship rules are less well defined than generally assumed. Why counting impact points from publication lists if these do not reflect your previous work?

I always thought that toll like receptors owe their name to the toll function of the immune system. As I learned only today, the origin is with the German “toll” (amazing, phantastic) ascribed by Christiane Nüsslein-Volhard to a Drosophila protein.