Most of the medical research into causes of allergy is more or less irrelevant to allergy sufferers. Here is an exception [author] if you are suffering from atopic dermatitis [paper] Continue reading Fabrics for atopic dermatitis
If you do have the same problem like me – operating a computer, pointing towards a wall and looking at the same time at an audience is somewhat odd – here may be a solution for you.
Initially found this at a blog with some java source code.
Another video example is
with abandonded C# code that compiled nicely on my mac (laserinteraction). Experiments are ongoing…
An (anonymous) reviewer of our forthcoming EJHG paper on IgE and STAT3 pointed me towards a JNCI paper that has a nice supplement – an excel sheet to calculate the probability that a positive report is false. It basically relies on (i) the magnitude of the p-value (ii) statistical power and (iii) fraction of tested hypothesis. While we certainly know (i) and (ii), (iii) is always hard to know with many datasets including hundreds of traits that allow indefinite numbers of subgroups. Are you really interested in a new paper about “An African-specific functional polymorphism in KCNMB1 shows sex-specific association with asthma severity” that encompasses 1 of virtually 100 ethnic groups; 1 or virtually 25000 genes; 1 of 2 sexes; 1 or virtually 50 asthma related traits, yea, yea.
This R script will parse plink‘s GC adjusted output to a GFF file that can be uploaded as genome browser track file. Just adjust the pathname at the beginning…
script
|wj_gwa.R|
A new Edge article answers this question. According to Chris Anderson, we are at “the end of science”, that is, science as we know it.
The quest for knowledge used to begin with grand theories. Now it begins with massive amounts of data. Welcome to the Petabyte Age.
Yesterday I reviewed a paper that crunches massive amount of data (and even found a new pathway for asthma). Nevertheless I was asking the question if this wishful thinking? Just take the next gene in one region and the overnext in another one and I would come up with a completely different pathway. This is all about association and not by the traditional “theorize, model, test it” way of science we have been brought along, yea, yea.
Besides traditional and expensive epidemiological studies to compare disease prevalence over time, the net offers also some nice research tools – click on the thumbnail to see Google asthma trend results by today. The query counts are largely consistent with most recent scientific papers seeing the asthma epidemic now at a (high) plateau. Did the environmental risk now saturate all individuals at risk?
It is a fact that the best climbs are performed by famous mountaineers before they became famous (Doug Scott in “Mountain” according to an inscription at Firmian/Messner Mountain Museum). Continue reading The best climbs
May 29, 2008 Nature has an interesting commentary by Peter Lawrence (66) about the archaic practice of retirement of active scientists at a determined age. It is a quite luxurious habit of “Doing what I like” while having a mostly pleasant life here on earth as a scientist, it may be a quite logical to prolong the scientific career.
Continue reading Retire retirement
Wolfram Henn, Vorsitzender der Kommission für Grundpositionen und ethische Fragen der Deutschen Gesellschaft für Humangenetik, warnt im Interview mit Technology Review (Ausgabe 07/08 […]) vor persönlichen Genomanalysen, die über das Internet angeboten werden. So bietet beispielsweise das Unternehmen 23andMe seit kurzem eine Genomanalyse für nur 999 Dollar an.
Welcome in the club! Just to let you know that 23andme has been stopped 2 days ago as reported by Spiegel magazine.
Given my interest in strange phenomena leading to science misperception I wonder why I didn’t find this site earlier as it tells you also everything about Déjà Vu, Déjà Vécu, Déjà Visité, L’esprit de l’Escalier (comeback when it is too late), Capgras delusion (replaced friend), Fregoli delusion (same person appears in different bodies) and prosopagnosia (unable to recognize faces also known as myopia…). Yea, yea.
Here is a new journal that I like very much – JOVE, the Journal of Visualized Experiments. A click on the snapshot will lead you right to its home and a lot of interesting videos.
Enhancing peer review is the main purpose of a new NIH website
there had been a pervasive sense that peer review service has become more of a chore than a stimulating and privileged experience. […] As we contemplated possible changes, we were guided by two fundamental principles. Continue reading Fund the best science, by the best scientists
Aren’t hat good news being published by Science this week?
Process-specific training can improve performance on untrained tasks, but the magnitude of gain is variable and often there is no transfer at all. We demonstrate transfer to a 3-back test of working memory after 5 weeks of training in updating. The transfer effect was based on a joint training-related activity increase for the criterion (letter memory) and transfer tasks in a striatal region that also was recruited pretraining.
Continue reading Reading this blog will improve your academic skills
genetic-future has an excellent article why the recent genome scans failed (i) alleles with small effects? (ii) population differences? (iii) epistatic interactions? (iv) cnvs more relevant than snps? (v) epigenetic inheritance? (vi) disease heterogeneity? It is a thorough review better than everything Continue reading The many problems of GWAs
