Category Archives: Genetics

Genetics

When controls are no controls

So far in epidemiology case – control studies are defined by an approach where

… the past histories of patients (the cases) suffering from the condition of interest are compared to the past histories of persons (the controls) who do not have the condition of interest, but who otherwise resemble the cases in such particulars as age and sex ….

I usually explain controls as non-cases in the same overall environment Continue reading When controls are no controls →

 

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Genetics

1% decoded

Nature web focus today reports an overview of the four year project Encode (ENCyclopedia Of DNA Elements) that tried to identify all functional elements in 1% of the human genome. In addition, there are 28 companion papers in the June 2007 issue of Genome Research. The Nature issue includes a pull-out poster featuring a screenshot of the UCSC Genome Browser.
I am still in the process of reading all the GWA studies, so don´t expect any intelligent remarks. The main point seems to be that the majority of the human genome is being transcribed which is in sharp contrast to the textbooks (Strachan/Read IInd ed, p142 says that only ~3% of the nuclear genome is being transcribed). Using gene centric SNP panels in some of the GWAs therefore have not been such a good idea, yea, yea.

 

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Genetics, Vitamins

Turning pale

Humans have always been attracted by white animals, tigers, elephants and crocodiles (BTW great melanosome pictures can be found at PLOS.
There seem to be also some evidence that light skin developed only recently as reported in a meeting report in Science by April, 20 based on sweeps around SLC24A5. This is somewhat in contrast to findings published more or less at the same time by the same group (but not mentioned in the meetings report) that a highly complex network is influencing skin color. Continue reading Turning pale →

 

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Allergy, Genetics, Philosophy

The third largest problem in epidemiology

-moblog- In my view, epidemiology is not very flexible to adjust to new methods and new techniques. Following some discussion that I had today with STW about eQTLs (quantitative traits derived by RNA microarrays or metabolome profiles) and JMA about system biology, it is likely that we are facing huge changes. Phenotypes may no more called intermediary and we may soon forget old controversies of disease definition. We will instead use new system-terms like NonImm076Trig31Ste0098 or TLR9-096321-Auto5337. Yea, yea.

 

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Allergy, Genetics

Lactase variants in Europe – any connection to allergy?

I will present this poster next Monday in San Francisco at the Annual Conference of the American Thoracic Society. Continue reading Lactase variants in Europe – any connection to allergy? →

 

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Genetics, Philosophy

A sense for justice

Hans-Werner Bierhoff (in a recent ZEIT interview) believes that our ability to recognise a punishment as fair/just or not fair/just depends on social norms. The ultimate driving force to sense justice, however, seems to be an inborn trait. I even believe in a QTL – a quantitative trait that can clearly defined and even mapped some time to distinct genetic variants.
Monkeys reject unequal pay (scienceblog:doi:10.1038/nature01963:) in the famous Brosnan study – why should humans do?
More details may be found at tit-for-tat.

 

CC-BY-NC Science Surf accessed 21.12.2025