Category Archives: Philosophy

Formal proof is difficult if not impossible

At least in medicine but also in many other fields, formal proof of a scientific hypothesis is difficult if not impossible. Reading again Greaves’ cancer book, I discover even more insights there. Talking about the hormonal stress leading to breast cancer he makes the point that

there is no ’cause’ in the straightforward, singular, or usually perceived meaning of the word; no tubercle bacillus equivalent. Neither is a mutant gene the common cause. Chronic hormonal stimulation driving persistent epithelial stem cell division seems to be a major factor (cycles driving cycles) and this reflects in large measure our social divorce from evolutionary adaptations for reproduction … Superimpose some degree of inherited predisposition and chance itself on this prescription and a very plausible causal network imbued with evolutionary principles becomes evident.

This is a very different view to the current sequencing headlines like “Lung cancer and melanoma laid bare“.

Do we need scientific journals at social networks?

It is interesting to see, how journals are trying to increase their market visibility – Nature has becoming famous for their investment in Second Life? Just recently I received an email that JACI – the Journal of Allergy and Clinical Immunology – has now opened an account at Facebook. Continue reading Do we need scientific journals at social networks?

People are, in a sense, on stage

— a quote of a new FM article entitled “Looking for you” that sees blogs as a form fo self-presentation on the internet (blogs btw show a dramatic increase of 1,4 new blogs every second worldwide). I haven’t seen blogging activity so much as Continue reading People are, in a sense, on stage

Why some women look young for their age

Here is my bit for the Ig Nobel – that piece that has just been published at PLoS ONE:

We studied the facial appearance of 102 pairs of female Danish twins aged 59 to 81 as well as 162 British females aged 45 to 75. Continue reading Why some women look young for their age

Coordinates of truth and hypothesis-generating research

An interesting piece published in Science finds that

The accuracy and predictability of a hypothesis depend on the validity of the inputs used to generate and test it. Because problems are typically complex and information regarding their solution is limited, the solution is more likely to be found if the information base is greater. This rationale is a driving force behind systems biology, which attempts to define biological complexity from a systemic perspective using information technology … High-profile journals publish systems biology studies, including the human genome sequence, but most papers focus on hypothesis-driven investigations.

The most remarkable point here is the fact that there are still more people who believe in an underlying truth. This reminds me to the philosopher Continue reading Coordinates of truth and hypothesis-generating research

Unscientific World

A review of “Unscientific America” on p 678 in Science Magazine 7 Aug 2009 finds

According to Mooney and Kirshenbaum, atheistic scientists such as Richard Dawkins and P. Z. Myers [who runs the immensely popular science blog Pharyngula] drive people away from science by forcing them to choose between the facts and their faith.

evo-devo-dis

I am curently working on a new lecture series on that topic – having a gut feeling that the evolutionary history will explain how and why we get diseases. Some German magazines (“Fehlkonstruktion Mensch” DER SPIEGEL 40/2009) even write about that topic quoting a forthcoming book of Ganten / Deichmann / Spahl). I will rely, however, mostly on Continue reading evo-devo-dis

First major publisher releases article metrics

From a press release

Today, the open-access publisher the Public Library of Science (PLoS; www.plos.org), announces the release of an expanded set of article-level metrics Continue reading First major publisher releases article metrics

Vanish

Finally, here is a technical solution to a proposal that I made here earlier

Ok, we are aware that recovery is always possible with cut & paste into other applications or printing a text -so we may better think about some watermarked graphics. “Don’t ever say anything on e-mail or text messaging that you don’t want to come back and bite you.”

Attention grabbing headlines

NI has an editorial on hyping research

Although these attention-grabbing headlines might help sell papers and increase traffic to newspaper websites, such reporting is irresponsible to the public and to science in general. Even if the article itself is more balanced, it must be remembered that many readers never get much beyond the headline. The net result is the public comes away with much misinformation.

Continue reading Attention grabbing headlines

Absence of evidence is not evidence of absence

I have just discovered that the book of Helmut Kiene”Komplementäre Methodenlehre der klinischen Forschung. Cognition-based Medicine. Berlin – Heidelberg – New York: Springer; 2001, 193 S. ISBN 3-540-41022-8 is now being online available as PDF – a must read for all clinical researchers.

Addendum 26 Feb 2021

Sorry for the title that involuntarily replicated a title from paper published already 14 years before  https://pubmed.ncbi.nlm.nih.gov/7647644/

Rejection hurts. Why everybody needs somebody

515 citations of an article in 5 years – it is timely to revisit “Does Rejection Hurt? An fMRI Study of Social Exclusion” by Eisenberger in Science magazine. I was refered to that study by “Lob der Schule” (an excellent book).

Participants were scanned while playing a virtual ball-tossing game in which they were ultimately excluded. Paralleling results from physical pain studies, the anterior cingulate cortex (ACC) was more active during exclusion.

These are bad news for all victims of workplace bullying or university harassment – their brains will react like under stimulation of physical harm leading to aggression as found in many studies

A wide variety of studies with animal as well as human subjects demonstrate that pain often gives rise to an inclination to hurt an available target, and also, at the human level, that people in pain are apt to be angry.

So, the final aggression of the victim is used to further isolate it – a vicious circle.

Rolling Stones

Blues Brothers

10.1.2019 revisited

The facts seem to be now largely accepted, see an article in Psychology Today: Is Social Pain Real Pain? and the 2012 review by Eisenberger. More recently some authors even think that “The salience of self, not social pain, is encoded by dorsal anterior cingulate and insula“.