Born to be write

A decade ago Karen Hunter (at that time Senior Vice President of Elsevier) did a brilliant analysis why scientists publish:

For academic scientists, the research paradigm is the experiment and the publication output is a journal article. Academic science researchers publish to establish their claim at a specific time to a specific result. They publish to gain other forms of recognition (such as promotion and tenure) that require publication. They publish in order to have independent certification of the results and to have those certified (refereed) results archived in perpetuity. Finally, they publish to communicate with those who may be interested in their works today …

She continues with another important aspect

… not the circle of cognoscenti (who do not need publication to be informed) but researchers in related fields, researchers in less well-connected institutions and students working their way into the inner ring.

In my opinion, the “claim at a specific time to a specific result” is probably the most relevant motivation for a scientist. Nevertheless having claims on ideas presented in a printed paper seems to be still a habit of the pre 1995 stone age of scientific publishing. Databases will be certainly as reliable in the future as printed paper. I guess that in 50 years the access to current electronic documents will be even better than to any printed paper. Yea, yea.


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On the limits of science

Have you ever heard of the Wikipedia Knowledge Dump? With the headline “WikiDumper: The Official Appreciation Page for the Best of the Wikipedia Rejects. One man’s trash is another man’s treasure” Dr. Cliff Pickover collects the best entries. For example you can read about the Beard Theorem that suggests that the size of one’s beard has a direct correlation to the radicality of a person’s socialist views. The site is as good as the Ig Noble, yea, yea.


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Can anybody become a Nobel Prize winner?

Anders Sandberg attended a seminar in Stockholm and has written an interesting report. I have doubts if we have so much need for heroes. There are so many prizes that you can apply for – an impressive list of prizes and honours that you can find at the CVs of some laureates: Albert Lasker Award, Paul Ehrlich Prize, and many, many more. Google returns 60.100.000 hits if you search for “science prize” and there is now even the European database of science prizes that will find a prize for every scientist. Yea, yea.


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WordPress as CMS

I have read many useful (and also some less useful) comments how to squeeze WordPress to work as a CMS.

I did not want to make any major changes to scripts that would be lost after an upgrade. I did not want to have extra plugins to change home (for example by creating an overriding home.cfm). I did not want to have any new categories. I did not want to change permalink structure. I still need my directory plugin to work, I still need the blog (some redirects even loose the blog address!) and I wanted to keep the RSS feed.

After several hours I came up with an very simple solution: Take a standard page and rename its title and slug to “Home” – assign a special “Home” template – redirect htaccess to this page. The only trick is to make the “Home” template work: it is basically a copy of the index.cfm in your WordPress theme directory where the line calling loop.php is being replaced with a slightly modifed loop code.

myblog.php
|wj_myblog.php|


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HUGO Changing Offensive Gene Names

Hsien Hsien Lei has a good comment on gene names approved by Human Genome Organisation (HUGO) Gene Nomenclature Committee which are nevertheless offending . Some of the inappropriate names are LFNG – lunatic fringe homolog (Drosophila), MFNG manic fringe homolog (Drosophila) as well as SHH sonic hedgehog homolog (Drosophila). There are many more names that arise only from a particular culture (like death executioner Bcl-2); it seems also a particular kind of humour to call a deaf mouse Beethoven. Yea, yea.


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Our knowledge springs from two main sources

Immanuel Kant is now also online in English language

Our knowledge springs from two main sources in the mind, first of which is the faculty or power of receiving representations (receptivity for impressions); the second is the power of cognizing by means of these representations (spontaneity in the production of conceptions). Through the first an object is given to us; through the second, it is, in relation to the representation (which is a mere determination of the mind), thought. Intuition and conceptions constitute, therefore, the elements of all our knowledge, so that neither conceptions without an intuition in some way corresponding to them, nor intuition without conceptions, can afford us a cognition.


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Why we should believe professional cyclists

I renember a nice meeting in South Sardinia in 2002 (see my figure below) where a lot of famous people gathered for interesting talks in a wonderful surrounding.
A spin off from this Ogliastra Genetics Park – as the authors called it – is now a paper in PLOS Genetics that examines the heritability of 98 quantitative cardiovascular traits in 6,148 Sardinians.
Although the authors did not measure hematocrit, RBC related counts had an extremely high heritability (MCV 0.76, MCH 0.78). Hemoglobin was somewhat lower (0.47) which might in part be attributable due to some local selection factors. This result comes largely unexpected, as the high heritability of the MCV was not known so far.
In the absence of any assay for exogeneous EPO, hematocrit is used as an indirect parameter for testing athletes. I already wondered why cyclists are having such high values (if we exclude illegal drug use). This seems to be a genetically trait by self-selection – an anemic cyclist will not participate in the Tour de France. Yea, yea.

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Addendum

Here is an answer to the question what makes a champion ;-)
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On the “Self”

If I would ever find the time, I would write a book on the “self”. Inspired by the Eccles/Popper book that I bought as a student, I always wondered how different the self is being defined in sociology, psychology/psychiatry, philosophy and theology.
As my current focus is more on genetics and immunology, I found a paper by Francisco Borrego on the “missing self” quite interesting as it highlights the genetic self is determined mainly by MHC class I molecules, where only NK cells transfected with H-2Dd were able to confer resistance for being self-attacked. It would be nice if other disciplines could also provide such simple answers, yea, yea.

Addendum

I have another suggestion: Zfp608 protects mouse mothers against immune-mediated attack by fetal cells.

Is there also a “digiself“?

Our identity has, for many years, existed quite independent of our physical incarnation in government, financial and other institutional databases. We are not real to the bank or other authorities unless we can produce something that links our physical self to our “real identity” in their database. We have many versions of this digital identity – or digiSelf, as I like to call it – spread among many databases, each with its unique characteristics, and inferred behaviours. Each one is more real to the institution – and ironically, to the people in that institution – than our physical self, what we consider to be our real self.


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Sex, drugs and DNA: Science’s Taboos Confronted

Highly recommended by a friend, I have ordered “Sex, drugs and DNA” by Michael Stebbins. Also Publishers Weekly finds
Continue reading Sex, drugs and DNA: Science’s Taboos Confronted


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Dr. Google

Googling for a diagnosis? The results are not too bad if you believe in a new BMJ report. The authors measured the percentage of correct diagnoses from Google searches compared with the correct diagnoses of 26 cases published in the New England Journal of Medicine. Google searches revealed the correct diagnosis in 15 (58%) cases.
Continue reading Dr. Google


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