First allergy cell found

A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders

Allergen-specific type 2 helper T (TH2) cells play a central role in initiating and orchestrating the allergic and asth-matic inflammatory response pathways. One major factor limiting the use of such atopic disease-causing T cells as both therapeutic targets and clinically useful biomarkers is the lack of an accepted methodology to identify and differentiate these cells from overall nonpathogenic TH2 cell types. We have described a subset of human memory TH2 cells confined to atopic individuals that includes all allergen-specific TH2 cells. These cells are terminally differ-entiated CD4+ T cells (CD27− and CD45RB−) characterized by coexpression of CRTH2, CD49d, and CD161 and exhibit numerous functional attributes distinct from conventional TH2 cells. Hence, we have denoted these cells with this stable allergic disease-related phenotype as the TH2A cell subset.

Sounds promising…

Hygiene hypothesis should be death but is still alive

There is a new paper today “The Hygiene Hypothesis in the Age of the Microbiome“. Fortunately there is a strong paywall…

An impressive illustration of the hygiene hypothesis was found in the consistent farm effect on asthma and allergies, which has partly been attributed to immunomodulatory properties of endotoxin as emitted by livestock.

which is not aware of “Time to abandon the hygiene hypothesis: new perspectives on allergic disease, the human microbiome, infectious disease prevention and the role of targeted hygiene

Although evidence supports the concept of immune regulation driven by microbe–host interactions, the term ‘hygiene hypothesis’ is a misleading misnomer.

see also “News Feature: Cleaning up the hygiene hypothesis

Still, the catchy hygiene hypothesis continues to be widely embraced by the public, the media, and even scientists: Uses of the term in the scientific literature rose threefold over the past 10 years compared with the decade prior, according to a search on Thomson Reuters Web of Science. “In science, when something has been propagated for so long, it can be hard to change,” says Marsha Wills-Karp, chair of environmental health and engineering at Johns Hopkins Bloomberg School of Public Health.

Timeline asthma / allergy genetics

First genetic study
1923 AF. Coca, J Immunol 8:163-171

First Linkage Study (AB0 blood group)
1936. I. Zieve, Ann Hum Gen 7:4074, 163-178

First Molecular Study (HLA)
1973 D. Marsh, Science 179:4074, 691-3

Second Linkage Study (AB0 blood group?)
1986, H. Eiberg ?

Third Linkage Study (11q31)
1989 W. Cookson, Lancet 1:8650, 1292-5

First  Modern Family Study
1992 S. Dold,  Arch Dis Child 67:8, 1018-22

First gene (Fc∈RI-β)
1993 A.J.Sandford,  The Lancet  341:8, 332-334

First true gene (IL4)
1994 D. Marsh, Science 264:5162, 1152-6

First Genomewide Linkage Scan
1996 S. Daniels,  Nature 383:6597, 247-50

Transatlantic Airway Conference Key Biscaine FL
1997 N. Zamel (unpublished results)

Second Genomewide Linkage Scan
1997 CSGA  Nature Genetics 15:389-392

Third Genomewide Linkage Scan
1999 M. Wjst,  Genomics 58:1-8

First GWAS
2007 M. Moffatt, Nat Genet 15:389-392


Phantom reference

There is an interesting story at A conference template with a dummy reference, that was supposed to be edited by abstract authors, was finally cited by 400 authors :) I find even more citations at Google Scholar, 703 to be exact. Low  quality, missing  control, careless editing, and fake journals, creepy…

Open letter to the Sente developer

Dear Michael J. Cinkosky,

this is an open letter regarding Sente academic library software.

Sente is used by tens of thousands of researchers in all academic fields at universities and research organizations around the world

I am using Sente nearly every day for many years to collect and annotate the literature.

It is useful to retrieve papers and insert references in my own papers.

It seems that Sente is not more supported.

A while ago, I could build up a bibliography only in exports from my text processor.

Then online sync stopped.

Most recently also Google Scholar reference recognition ended.

It is now a useless software. I paid for it, I used it, which was a fair deal.

But now am now lost, if Sente just drowns in the internet.

Could you sell it to a company that continues support?

Your customer base would really appreciate it.

Or write a final countdown Endnote export script that preserves PDF links.

Or just give us the code at Github, we will continue to develop it.

We all appreciate your work with Genbank and also with Sente.

But don’t leave us without saying good-bye.

All the best,