According to Wikipedia on May 24, 1844 Samuel Morse sent his famous words “What hath God wrought” from the B&O’s Baltimore station to the Capitol Building along the wire – the first email. Continue reading First email or the driving force of science
of science even computer nerds would need just one single word processor Continue reading In a perfect world
Visiting again the British Library Humanities Reading Room last week, I had a major problem securing my laptop as it has no Kensington slot. I haven’t found anything useful for locking it except this free (car-like antitheft)Lockdown application. If you are not too much paranoid – it is a clever solution – and a lot of fun here back in the lab to watch the pictures it takes.
Found some lock brackets here.
Two days ago I heard an interesting by Andreas Beyer about using wiring diagrams as a bioinformatics tool box for simulating complex biological relationships. This is something that can be found also in this recent nat gen review but even more detailed in new work on eQTLs. So far, however, there is not proof that any of these methods behave much better than others in the absence of a gold standard in bioinformatics, yea, yea.
A small luxurious law here in Germany – we may further offer limited documents to limited participants according to Heise news Continue reading Intranet exception
After a long time (to be exact: 27 years of Microsoft and 12 years of Linux use) I decided to switch to a Macbook Air. That may be an aesthetic decision (as buying an A4, a Nomos, a Bose or whatelse) :-) but may be heavily influenced of my obsession for lightweight and durable equipment. Continue reading Alt – Command – Escape
It seems that there are two numbering systems in humans – a general sense of numbers for some quick and dirty estimates and some more genuine computation skills of showing the result of (2327)^2. At least the first capacity seems to be inborn (and an important survival skill). According a recent SZ article (29th Sept 2008) a host of new studies now show that
the two number systems, the bestial and celestial, may be profoundly related, an insight with potentially broad implications for math education
and as I believe – for science in general as most science fields are being dominated by the Fermi problem. Continue reading Basic instinct for math?
For the first time, I found some data about “bench to bedside” transit times. Of 101 promising claims between 1979 and 1983, there have been only 5 clinical interventions in 2003 and only 1 had extensive clinical used; mean lag time 24 years, yea, yea.
Genowatch (paper|website) is doing pretty well by annotating large SNP sets that would require otherwise numerous hours to map their position on genes, biological function and pathways. Continue reading SNP batch annotation of GWAs
Galaxy, one of my favorite bioinformatics websites now offers the conversion of existing history into a work flow. Obviously source data (by UCSC or Ensembl) may be produced in the same format but everything else can then be delegated to a workflow – just a set of instructions how to modify your data.
As somebody who is dealing most time with large datasets I always arrive at genes and proteins that I do not know. Using Biocarta, Keggs and other services in the past, I find the new WikiPathways exciting and hope that it will grow over the years. A companion paper in PLoS biology describes its roots in GenMAPP and the current work of the authors on bots that identifiy inconsistencies but also pick up loose ends. Hopefully I will find some time to work a bit on nuclear receptors, yea, yea.
Having been asked now by several people, I am compiling here a list of programs can be used for CNV calling. Continue reading CNV (not London) calling
If you do have the same problem like me – operating a computer, pointing towards a wall and looking at the same time at an audience is somewhat odd – here may be a solution for you.
Initially found this at a blog with some java source code.
Another video example is
with abandonded C# code that compiled nicely on my mac (laserinteraction). Experiments are ongoing…
Here is a new journal that I like very much – JOVE, the Journal of Visualized Experiments. A click on the snapshot will lead you right to its home and a lot of interesting videos.
Feed this paper at this site to get the following result
