Wie oft habe ich den Satz in den letzten Wochen schon gehört… und er wird durch die häufige Wiederholung nicht richtiger. Denn natürlich habe ich etwas zu verbergen, wie die meisten Menschen, ich bin sogar vom Staat zum Arztgeheimnis verpflichtet worden.
Hier kommt jedenfalls ein sehr detailliertes Video für alle “die nichts zu verbergen haben”.
Size of diploid human genome: 2 x 3 billion bp = 6 billion bp
Average size of of nucleotides: 487 + 159 g/mol = 646 g/mol
Single cell DNA amount: 6 billion * 646 g/mol = 3.87 pg
In 25 ng PCR human genomic DNA : 25000 pg / 3.87 pg = 6459 copies
Es ist ein großartiges Buch, das Esther Maria Magnis geschrieben hat. Sprachmächtig, mit starken Bildern, nimmt uns Esther Magnis mit in die Tiefe ihres Erlebens.
Es ist eine der stärksten Stellen am Ende des Buches, wo nie die Rede davon war, dass es auf der Erde witzig sein wird und unser Glauben, der Glauben der Christen einen Schrecken hat, nämlich das Wissen um den ganzen Dreck der Welt.
Vielleicht ist auch Esther in Wirklichkeit ein Pseudonm, ein Pseudonym für Ijob? Die unglaublich direkte Anklage Gottes. Und Ijob, der sich zur Wand dreht und nicht mehr leben will. Erst durch Elihu fasst er wieder Mut. Dabei stellt Elihu das Recht des Menschen in Frage, das göttliches Wirken zu beurteilen, und zwar grundsätzlich, da die Frage nach dem Grund für das Leid nur als Frage zu dem Zweck des Leides formuliert werden kann.
Unnachahmlich auch Ihre Sicht der Evangelien, die sie als extrem schräg bezeichnet – viermal nebeneinander wie Zeugenaussagen nach einem Unfall, der in der Tat ziemlich echt wirkt. Von den vielen beschaulichen Jesus Büchern, von Schweitzers Geschichte der Leben Jesu Forschung bis zu Ratzingers Jesus von Nazareth, hat das kaum jemand so sehr auf den Punkt gebracht.
Und sie traut sich was.
Und wenn Du schreist “Es gibt keine Wahrheit”, dann beweis mir die Wahrheit an dem Satz, und wenn Du es nicht kannst, dann geh zurück in die Gräber… Und Du wirst nicht viele finden, die darauf bestehen, dass Wahrheit relativ ist, wenn es darum geht, ob man ihre Kinder foltern, ficken und fressen darf. Sie werden relativ klar, sie werden ziemlich bestimmt den Anspruch haben, die Wahrheit zu sagen, dass das ein Verbrechen wäre. Sie werden sogar <böse> sagen und es überkulturell, überkonfessionell, über den Zeiten und oberhalb der Meinungen ansiedeln. Ich weiss nicht viel. Ich weiss nicht was gut und böse ist. Ich habe Ahnungen, ich habe die Wahrheit nicht.
Magnis, Esther Maria: Gott braucht dich nicht. Eine Bekehrung, Rowohlt Verlag, 238 S., ISBN 978-3-498-06406-8, 16,95 Euro
e! Science News reports a new study in EPJ Data Science by Marcel Salathé showing that anti-vaccination sentiments spread more easily than pro-vaccination sentiments.
We find that the effects of neighborhood size and exposure intensity are qualitatively very different depending on the type of sentiment. Generally, we find that larger numbers of opinionated neighbors inhibit the expression of sentiments. We also find that exposure to negative sentiment is contagious
Read the full paper for the tricky design – at least the results fully underpin daily life experience. It’s certainly much easier to do Twitter than Facebook studies on the other hand these rather short messages are certainly not the main channel of many great “opinionated” people.
The turn of the year may not only indicate many new chances but also allow a higher standpoint. IMHO the best paper in the vitamin field was published by Rousseau Gama in the BMJ 2012;345 :e5706.
We measured serum C reactive protein and 25-hydroxyvitamin D concentrations before and two days after elective knee or hip surgery in 30 patients. After surgery the mean serum concentration of C reactive protein increased (5.0 (SD 5.5) v 116.0 (81.2) mg/L; P <0.0001), whereas serum 25-hydroxyvitamin D decreased (56.2 (30.3) v 46.0 (27.6) nmol/L; P <0.0006).
The reasons are not fully clear but the results are consistent with two other studies reporting a fall in serum 25-hydroxyvitamin D concentration during a systemic inflammatory response. So, it looks like 1 simple study will make 1000 other studies useless. That seems to be the beauty of science… although I do not understand how that related to a serum half-life of two weeks?
So far I argued that vitamin D is always a lifestyle proxy e.g. pubmed/22698792) but there maybe also biological reasons.
BTW I would also have a candidate for the worst vitamin D paper, just in case, ….
Genomes Unzipped just published guidelines for tweeting at conferences.
Check the conference social media guidelines first. Continue reading A new dress code, ahem write code, for conferences
We were recently dicussing that problem too what Nature writes about the Encode project:
The question is, where to stop? Kellis says that some experimental approaches could hit saturation points: if the rate of discoveries falls below a certain threshold, the return on each experiment could become too low to pursue
As always – the scientific method once invoked – creates beautiful results but when it comes to justification of programs or methods it’s all about personal preferences, irrational beliefs, common misunderstandings, conformance to general trends, and whatsoever non-scientific influences.
Retractions are increasing anytime I look around retraction watch. A new PNAS paper now has the most thorough analysis of retractions:
A detailed review of all 2,047 biomedical and life-science research articles indexed by PubMed as retracted on May 3, 2012 revealed that only 21.3% of retractions were attributable to error. In contrast, 67.4% of retractions were attributable to misconduct, including fraud or suspected fraud (43.4%), duplicate publication (14.2%), and plagiarism (9.8%) …fraud has increased ∼10-fold since 1975.
So, fraud is the most frequent cause – and it usually does not come isolated Continue reading The true reason for retractions?
Found an interesting comment in Nature Sept, 13, p177
All existing metrics capture only what a scientist has done, not what he or she would be able capable to.
I am not sure Continue reading A future predicting metrics for scientists?
received that today / das kam heute morgen an
The idea might not be new – we already diluted DNA already a decade ago ( see this 2003 paper ). A new Nature paper by Peters ( Accurate whole-genome sequencing and haplotyping from 10 to 20 human cells… ) now shows that diluting DNA into 384 wells, adding unique tags, and pooling again before sequencing everything on a Hiseq, will result in an enormous reduction of sequencing errors – a problem that we are fighting now for a year. IMHO the paper isn’t primarily about the low number of cells that can be sequenced, but also about error reduction in WGS. The two key facts are certainly
To ensure complete representation of the genome we maximized the input of DNA fragments for a given read coverage and number of aliquots. Unlike other experimental approaches this resulted in low- coverage read data for each fragment in each of the wells a fragment is found in.
plus an intelligent phasing algorithm Continue reading An enormous step forward in whole genome sequencing
The EU is supporting Open Access too. 12431 scientists already signed the petition at http://www.thecostofknowledge.com by today!
Continue reading EU supporting Open Access
There are so cute little files while I am constantly looking up addresses in travel guides, madly identifying them at google earth before transferring location bookmarks to my mobile devices.
Why can’t publishers produce just some small geo.kml or geo.rdf files, deposit them somewhere on their web server and link them with barcodes that are printed each time a geolocation is referred too (example link Groebenzell)?
The iPhone needs a slightly different form (without kml) as well as an app like i-nigma that is pointed by this barcode
to maps://?geocode=&q=gr%C3%B6benzell&ie=UTF8&client=safari&oe=UTF-8&hnear=Gr%C3%B6benzell,+Oberbayern,+Bayern&gl=de&t=m&z=14”>Groebenzell.