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correspondence nature genetics
the era of modern allergy genetics started in 1997 with the Transatlantic Airway Conference at Key Biscayne, Florida. 20 years later, the paper of Ferreira et al. (1) marks the end of an era by reporting the largest study so far of asthma, „hay fever“ and atopic eczema in 180,000 cases. It is the result of an huge international effort of many named and unnamed scientists. Unfortunately, there are major impairments regarding scope of analysis, epidemiological and bioinformatics methods, interpretation and data release. Some issues even contradict nature genetics editorial policies (2), (3), (4). Continue reading Nature Genetics corrupted by 23andme
Recently I encountered this strange error message in WordPress when trying to write a new post. Maybe I haven’t done any major changes, only removed a security plugin recently while the whole system is continuously updated.
Disabling all plugins and reverting to the standard twentyfifteen theme did not help. Inspection of post.php also did not show anything unusual (the indicated line number was probably wrong due to several includes). Googling the error message also did not help as these lead only to site specific problems. Continue reading Track down the “no object… error in post.php”
A detailed review of all 2,047 biomedical and life-science research articles indexed by PubMed as retracted on May 3, 2012 revealed that only 21.3% of retractions were attributable to error. In contrast, 67.4% of retractions were attributable to misconduct, including fraud or suspected fraud (43.4%), duplicate publication (14.2%), and plagiarism (9.8%) …fraud has increased ∼10-fold since 1975.
So, fraud is the most frequent cause – and it usually does not come isolated Continue reading The true reason for retractions?
The idea might not be new – we already diluted DNA already a decade ago ( see this 2003 paper ). A new Nature paper by Peters ( Accurate whole-genome sequencing and haplotyping from 10 to 20 human cells… ) now shows that diluting DNA into 384 wells, adding unique tags, and pooling again before sequencing everything on a Hiseq, will result in an enormous reduction of sequencing errors – a problem that we are fighting now for a year. IMHO the paper isn’t primarily about the low number of cells that can be sequenced, but also about error reduction in WGS. The two key facts are certainly
To ensure complete representation of the genome we maximized the input of DNA fragments for a given read coverage and number of aliquots. Unlike other experimental approaches this resulted in low- coverage read data for each fragment in each of the wells a fragment is found in.
plus an intelligent phasing algorithm Continue reading An enormous step forward in whole genome sequencing
I am struggling now for 4 weeks with some unusual behaviour in PLINK that gives me different results with a trait of the alternate phenotype files either by calling that trait directly
plink –file mydata –tdt –pheno pheno2.txt –mpheno 1
or from a loop over all traits
plink –file mydata –tdt –pheno pheno2.txt –all-pheno
It seems that I am working with different numbers at both occasions – click to enlarge the log Continue reading PLINK: Bug or feature?
Aurelius Augustinus: Irren ist menschlich, aber aus Leidenschaft im Irrtum zu verharren, ist teuflisch.
August von Kotzebue: Menschen irren, aber nur große Menschen erkennen ihren Irrtum.
Christian Friedrich Hebbel: Die Menschheit läßt sich keinen Irrtum nehmen, der ihr nützt.
Friedrich von Schiller: Liegt der Irrtum nur erst, wie ein Grundstein, unter dem Boden, immer baut man darauf, nimmermehr kömmt er an den Tag.
Friedrich von Schiller: Hundertmal wer ich’s euch sagen und tausendmal: Irrtum ist Irrtum! Ob ihn der größte Mann, ob ihn der kleinste beging.
Georg Christoph Lichtenberg: Nur der Betrug entehrt, der Irrtum nie.
Continue reading Errare humanum est