Here comes the link to a case report of surfer’s asthma (could not resist)
… We present the case of a 42-year-old man with a 2-year history of wheezing, chest tightness, and upper respiratory symptoms that were associated with surfing. Continue reading Surfer’s asthma
Blood pressure seems to have a complicated regulation according to a recent nature medicine editorial
If you ask a physiologist what organs are involved in blood pressure regulation, you will probably be told the kidney, the brain or the blood vessels. The kidney is responsible for handling sodium … The brain integrates afferent signals from peripheral sites such as the kidney … systemic vascular resistance is elevated in almost all adults with hypertension, suggesting that arteriolar vasoconstriction has an important role in this disease.
The editorial accompanies a new mechanistic report how a high-salt diet leads to interstitial hypertonic Na+ accumulation by activation of tonicity-responsive enhancer binding protein (TonEBP) binding the promoter of the gene encoding vascular endothelial growth factor-C (VEGF-C). As far, as good, Continue reading Forget about genes II
An AJHG paper that is already resting some longer time on my desk says that
Nonsense SNPs introduce premature termination codons into genes and can result in the absence of a gene product … Continue reading Forget about genes I
Still in the spirit of the last few posts, here comes something exciting: sciflies.org aims at
We look forward to receiving your application for funding of initial proof-of-concept STEM research projects in the range of $5,000 to $12,000. To participate in this unique online grassroots-funded opportunity, please complete the questionnaire about your project, including details of its possible outcome/impact and profiles of the researchers or research team.
but, sorry, I have to warn you – the website does NOT save your project – it took me 20 minutes to figure that out.
During my recent lecture series on science and religion, I tried to make clear that science includes many beliefs in addition to hard facts while religions encompasses hard facts in addition to many beliefs.
So what about the fuzzy approach of intuition or educated guess in a prototypical biological experiment? If this is not just a dose or time variation from a previous experiment, it will always involve an extrapolation from somewhat related facts believing that the next experiment will be better than the last Continue reading In-tui-tion, In-tui-fiction and educated guess
We will probably submit our IL-17 paper next week – so it was of interest to read a new paper in NJ that
demonstrate a protective function for IL-17 and identify T cells as not only the source but also a target of IL-17 in vivo
for inflammatory bowel disease. Asthma may, however, present a different situation.
or briefly vitamin D3. There seems to be another vitamin D /allergy abstract at the forthcoming EAACI congress from the KOALA study. The authors find
Risk for AD was highest for children in the fourth quintile of maternal 25(OH)D level [adjusted odds ratio (aOR) 2.08; 95%CI 1.07-4.03] compared to those in the third quintile; P for trend over the quintiles 0.03]. Continue reading (1S,3Z)-3-[(2E)-2-[(1R,3aR,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexan-1-ol
FYI – a citation from “Accountability of Research”
Using Natural Science and Engineering Research Council Canada (NSERC) statistics, we show that the $40,000 (Canadian) cost of preparation for a grant application and rejection by peer review in 2007 exceeded that of giving every qualified investigator a direct baseline discovery grant of $30,000 (average grant). This means the Canadian Federal Government could institute direct grants for 100% of qualified applicants for the same money. We anticipate that the net result would be more and better research since more research would be conducted at the critical idea or discovery stage.
Will that be ever read by our governments? Nay, nay.
SPQR (is not necessary to be remembered) but certainly TSLP – at least if you are interested in allergy research (see the discussion here 2 years ago) when we knew from a PNAS paper that topical vitamin D3 induces thymic stromal lymphopoietin and triggers atopic dermatitis (in mice). Now there is an update – TSLP even mediates the progression to experimental asthma
vitamin D3 … not only triggers AD as we previously reported but also aggravates experimental allergic asthma induced by ovalbumin sensitization and challenge. Our study, which provides a mouse model to study human “atopic march
will be continued after Continue reading T_S_L_P
The world is simultaneously infinitely horrible and infinitely wonderful – a short quote to promote this great online book on “Trauma and nonviolent social change” – power up “power-under.
Oppression is a social toxin which, through the mechanism of trauma, literally makes people sick. It is a sickness that causes massive personal suffering, and when left to its own devices it is self-perpetuating and severely impedes efforts to achieve social change. We need to understand how groups of people who have been traumatized by oppression can harness our traumatic experience in ways which enable us to build effective social change organizations and movements. We particularly need to find ways to transform traumatic rage into a constructive force – one which can serve both individual recovery and societal transformation.
I will propose the concept of constructive rage as a framework for addressing this challenge. I attempt in this chapter to present strategies for how to contain the destructive potentials of traumatic experience and power-under, and how to harness the power of traumatic rage as a force for liberation.
 |
Isn’t that a funny new category as reported in the last asthma genome scan – “same direction”? Should that provide evidence that isn’t there? Of 10 samples only one replicates (FHS) and one shows borderline (COP) association to PDE4D / rs 1588265.
yea, yea. |
The title already says it all – I think that poorly programmed software leads a lot of traces on the harddisk, in the memory and even on the CPU load.
It took me more than 1 hour and even several emails to figure where launchd starts this process:
Finally, just silence, several months after deinstallation of the client, yea, yea.
Frequently given answers – an article at Spiegel online has some of the answers you will need when being asked by research administratives or journalists for your work.
Please, please, please don’t try on my phone.
A quote assigned to Max Dellbrück (according to Kay’s 2000 Book of Life p194 – the letterhead of the RNA tie club). Isn’t that a wonderful MOTD? Yea, yea.
