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Too complicated for the rest of us
A new editorial in one of my most favorite journals now finds that immune cell signal transduction is just too complicated to be effectively queried using traditional methods and mindsets – something that I felt for some long time to be true not only for immunology for also for genetics, yea, yea.
Seoul update of the WMA declaration – you lost your rights
Having written in the last year a widely discussed paper about Informed Consent the new WMA revision #25 makes this rather waste paper:
For medical research using identifiable human material or data, physicians must normally seek consent for the collection, analysis, storage and/or reuse. There may be situations where consent would be impossible or impractical to obtain for such research or would pose a threat to the validity of the research. In such situations the research may be done only after consideration and approval of a research ethics committee.
With this paragraph in effect you can now to do every test on every sample that you possess. I will tell you from my practical experience how this work Continue reading Seoul update of the WMA declaration – you lost your rights
Three unwise monkeys
Thanks to the great audience in Washington DC watching our pro-con show about vitamin D and allergy. Are you still wondering about all the monkeys on my opponent’s slides? Me too…
With having fever from a flu on the way back to Europe, a picture came to my mind showing the 3 apes that are unable to see, hear and speak …
Mail me if there remain any doubts about the Th1 blocking effect of D3 or go to one of the recent reviews – I have take this for granted as it is even in standard textbooks like Roitt’s Immunology. Continue reading Three unwise monkeys
Clickstreams
An American team believes to describe science activity by web clicks on journal pages.
Over the course of 2007 and 2008, we collected nearly 1 billion user interactions recorded by the scholarly web portals of some of the most significant publishers, aggregators and institutional consortia.
with the conclusion Continue reading Clickstreams
Factory science
There seems to be a GWAS repository that has an entry of an asthma study otherwise not known in the biomedical literature and – as see on the screenshot -results tables are empty. Continue reading Factory science
A better search engine for science?
New rumors say about Wolfram alpha
In this respect it is vastly smarter than (and different from) Google. Google simply retrieves documents based on keyword searches. Google doesn’t understand the question or the answer, and doesn’t compute answers based on models of various fields of human knowledge.
…
or those who are more scientifically inclined, Stephen showed me many interesting examples — for example, Wolfram Alpha was able to solve novel numeric sequencing problems, calculus problems, and could answer questions about the human genome too.
I have applied for a test account as I am interested in methods how to deal with genomic and all the other pentabyte of data — we urgently need a paradigm shift as single genome prices will go down to 1000 €. Continue reading A better search engine for science?
It’s all math
Find more like this at morenewmath
Another link tip is “Cut the Not“.
So many advertisers
It’s a pleasant experience to write something that is being translated afterwards into so many languages afterwards. It is, however, irritating that this dissemination is irrespective of what I (and all second and third hand journalists and translators) understand of this curious world.

Still some time left?
There are many interesting objects at the virtual Science Museum covering the long history of medicine. The site is currently down but will hopefully be restored this night.
Is the Nobel prize predictable?
To be a Nobel candidate may be predictable if I am reading correctly a paper on archiv.org. The “traditional” impact factor is largely useless
as it ignores the importance of citing papers: a citation from an obscure paper is given the same weight as a citation from a ground-breaking and highly cited work
It may be, however, that the (PageRank derived) CiteRank is holding some promises – giving weight by whom you are cited. In this case, even a 100 citation paper can lead to a Nobel prize.
But is it predictable to get a Nobel prize candidate? Certainly not. I agree with a news feature about a science manager who
recently read Outliers, a book in which Malcolm Gladwell makes the case that
exceptional people get where they are partly because of the exceptional circumstances in which they find themselves, rather than through exceptional ability or sheer hard work.
Yea, yea.
Show off – the most important bias in research
A new editorial in PLoS medicine suggests five ways how trust in publications can be reestablished:
First, editors themselves should recognize and declare their own competing interests. Continue reading Show off – the most important bias in research
Pray tell us what you do
I already suspect that science has more to do with believes than religion. However, only very recently I came across this paper (when working on eosinophils) that stretches this view to its limits: “Eosinophil cells, pray tell us what you do!” Or is that a new incarnation of Spinoza’s God in Nature?
Interrupt yourself
or should I have said that science is nothing more than an extension of the senses? Or that most of our scientific output is done by autopilots?
Peer review – a charade?
quoting from an email this afternoon:
Only 8% members of the Scientific Research Society agreed that “peer review works well as it is.” (Chubin and Hackett, 1990; p.192).
“A recent U.S. Supreme Court decision and an analysis of the peer review system substantiate complaints about this fundamental aspect of scientific research.” (Horrobin, 2001).
Horrobin concludes that peer review “is a non-validated charade whose processes generate results little better than does chance.” (Horrobin, 2001). Continue reading Peer review – a charade?