Vitamin D as a treatment of tuberculosis

There is now a lot of hype around the usefulness of vitamin D in the treatment of tuberculosis (scienceblog:doi:10.1164/rccm.200701-007OC ). The authors mention even their previous review (scienceblog:doi:10.1016/j.jsbmb.2006.12.052:) summarizing 13 studies between 1947 and 1998. Continue reading Vitamin D as a treatment of tuberculosis

 

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Ending decay (and suffering)

It sounds unbelievable – not only to me but also to the editors of Nature who needed half a year to publish a paper of (probably the first true) genetic treatment. Two high-throughput screens comprising ~800,000 low molecular weight compounds were needed to identify 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid Continue reading Ending decay (and suffering)

 

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Physician’s industry dependency

The NEJM has an article about “A National Survey of Physician’s Industry Relationships” – a topic that I did not expect in the NEJM at least from what I have read during the recent change at the editorial office. That’s life – always a surprise. Continue reading Physician’s industry dependency

 

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Dont look at serum values alone

There is an ongoing discussion if 25-OH-D3 serum values can be used to diagnose vitamin D insufficiency. At least for rickets outcome there are now quantitatitive data that allow a comparison of clinical symptoms, radiological findings, cholecalciferol and alkaline phosphatase levels. I have rearranged the values of a new paper into the following figure Continue reading Dont look at serum values alone

 

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Random

What is a random figure? Computer may be biased when true random numbers are needed (for example for cryptography). Here is a truly random generator, use it at your own risk…

random.png

 

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Inferences for ratios of normal means

The last R newsletter (volume 7/1, April 2007) has a solution to a long standing problem. The new package mratios can deal now with ratios of means of normally distributed random variables and ratios of regression coefficients arise in a variety of ways. For two-sample problems, the package is capable of constructing confidence
intervals and performing the related tests when the group variances are assumed homogeneous or heterogeneous.

 

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No day without a line

seems to be the motto of many bloggers although it goes probably back to Pliny.
“Kein Tag ohne Präparat” (no day without taxidermy) was also the motto of Rudolf Virchow that I found last week in the Medizinhistorische Museum at Charité Berlin. More on this fascinating collection can be found at taz. No day without DNA is being the modern translation…
biobank.png

 

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