All posts by admin

Why I don’t have an iphone (yet)

Just recently I read an interesting blog entry of another internet veteran. I am reprinting here the main argument

The iPhone vision of the mobile Internet’s future omits controversy, sex, and freedom, but includes strict limits on who can know what and who can say what. It’s a sterile Disney-fied walled garden surrounded by sharp-toothed lawyers. The people who create the apps serve at the landlord’s pleasure and fear his anger. Continue reading Why I don’t have an iphone (yet)

 

CC-BY-NC Science Surf , accessed 24.03.2026

OSX 10.6, Macports, GD and finally Circos

I need live circos plotting for an upcoming seminar next year.
After installing the most recent xcode, a new macports and a fresh GD library, I issued on the command prompt

sudo port selfupdate
sudo port install gd2
which perl
sudo perl -MCPAN -e shell
cpan> install MD5
cpan> install YAML
cpan> install CPAN
cpan> reload cpan
cpan> install Clone
cpan> install GD
cpan> install GD::Polyline Continue reading OSX 10.6, Macports, GD and finally Circos

 

CC-BY-NC Science Surf , accessed 24.03.2026

On the impossibility of being expert

The BMJ christmas edition has again some nice papers – with a theoretical account on denialism and the next paper on the impossibility of being expert. This looks like the best joke there, sorry Tony, probably unintended.

Since Alvin Toffler coined the phrase “information overload” in 1970, the growth of scientific and medical information has been inexorable. There are now 25 400 journals in science, technology, and medicine, and their number is increasing by 3.5% a year; in 2009, they published 1.5 million articles. PubMed now cites more than 20 million papers.

Yea, yea.

 

CC-BY-NC Science Surf , accessed 24.03.2026

Keep secret

There is a new Edge Special Event about the Hillis’s question “WHO GETS TO KEEP SECRETS?”

The question of secrecy in the information age is clearly a deep social (and mathematical) problem, and well worth paying attention to.
When does my right to privacy trump your need for security?; Should a democratic government be allowed to practice secret diplomacy? Would we rather live in a world with guaranteed privacy or a world in which there are no secrets? If the answer is somewhere in between, how do we draw the line?

With all the wikileaks hype over the last year, the Edge essay is la perfect supplement to our last paper about anonymity in genetics – check out BMC Ethics “Caught you: Threats to confidentiality due to the public release of large-scale genetic data sets“.
What we didn’t mention in this paper are more complicated statistics like stochastic record linkage – more on that in RJournal 2/2010, p.61 ff

 

CC-BY-NC Science Surf , accessed 24.03.2026

Hygiene hypothesis – dead or alive?

It seems that I am not alone here to think that the hygiene hypothesis has thrown back allergy research for 20 years – despite the desperate attempts of journalists and scientists. Here is an an excerpt of Hygiene hypothesis: wanted—dead or alive

When it comes down to all, the best evidence to prove or dispute the hygiene hypothesis will probably come from ongoing and future randomized trials of interventions, e.g. treatment with probiotics and microbial products, that have been developed in the light of the hygiene hypothesis. In the mean time, we must prepare ourselves to face the results of these trials as well as of other types of evidence. It is a possibility that it may turn out that the hygiene hypothesis is more dead than alive, or at the least needs another revision.

 

CC-BY-NC Science Surf , accessed 24.03.2026

The largest study so far on serum cytokines

We just published the largest study so far of human serum cytokines providing for the first time reference values.

In this study we investigated serum samples from 944 individuals of 218 asthma-affected families by a multiplex, microsphere based system detecting at high sensitivity eleven asthma associated mediators: eotaxin (CCL11), granulocyte macrophage stimulating factor (GM-CSF), interferon gamma (IFNγ), interleukin-4 (IL-4), IL-5, IL-8, IL-10, IL-12 (p40), IL-13, IL-17 and tumor necrosis factor alpha (TNFα). Continue reading The largest study so far on serum cytokines

 

CC-BY-NC Science Surf , accessed 24.03.2026

Science – a belief system

I haven’t followed up most recent developments in philosophy and was therefore quite intrigued by a lecture of Hannes Leitgeb last week about “Reducing belief simpliciter to degrees of belief” – or should I say degrees of probability? Details about the lecture in my notes. While common sense would put belief more to the theology department, modern philosophers have a quite different position as he further explained me (and which are excellently summarized at plato.stanford.edu)

contemporary analytic philosophers of mind generally use the term “belief” to refer to the attitude we have, roughly, whenever we take something to be the case or regard it as true. To believe something, in this sense, needn’t involve actively reflecting on it: Of the vast number of things ordinary adults believe, only a few can be at the fore of the mind at any single time. Nor does the term “belief”, in standard philosophical usage, imply any uncertainty or any extended reflection about the matter in question (as it sometimes does in ordinary English usage). Many of the things we believe, in the relevant sense, are quite mundane: that we have heads, that it’s the 21st century, that a coffee mug is on the desk. Forming beliefs is thus one of the most basic and important features of the mind, and the concept of belief plays a crucial role in both philosophy of mind and epistemology.

Philosophers target a universal definition Continue reading Science – a belief system

 

CC-BY-NC Science Surf , accessed 24.03.2026

Getting most out of your money

Funding strategies are seldom reviewed. But note, there is a new paper in Nature “Follow the money” with an result that I find plausible:

In general, we find that sponsors who concentrate funds in fewer institutions have lower research impact as measured by early-citation counts. It may well be that when groups from multiple institutions vie for funding, competition increases, review processes become less partial and more promising projects are selected.

So, funding should not be concentrated too much (and together with an earlier finding here from the Ig Noble prize 2010) it even doesn’t matter whom to fund ;-)

 

CC-BY-NC Science Surf , accessed 24.03.2026

A CV without failure?

There is a great new proposal (although it will be never accepted in the scientific community)

Compile an ‘alternative’ CV of failures. Log every unsuccessful application, refused grant proposal and rejected paper. Don’t dwell on it for hours, just keep a running, up-to-date tally. If you dare — and can afford to — make it public. It will be six times as long as your normal CV.

tbc…

 

CC-BY-NC Science Surf , accessed 24.03.2026