Der chinesische Menschenversuch

Mittwoch 12.12.2018

Hinter einem Paywall, das “Wall Street Journal“.

Scientists Skeptical About Gene-Edited Baby Experiment. Experts who examined the data question whether the Chinese scientist was successful

Genomeweb mit Details

But this is still unclear, according to Ryder. “What we know from the deep sequencing data post-birth of the umbilical cord, the placenta, and the cord blood is that there are two genotypes [in Lulu],” he said. “There’s the -15 mutation and there’s the wildtype or the unedited gene. It could be that in other tissues there will be other genotypes that reveal themselves. Having looked more closely at the chromatograms of the sequencing from before implantation, it suggests that the embryos were in fact mosaic. I would say that it’s probably the case that she’s not going to be protected from HIV, and she could be heterozygous. It’s at least possible that half of the cells are completely edited, and half of the cells are unedited. And whether or not she’s protected depends upon what genotypes are present in her CD4+ T cells which are the cells that HIV infects.” “I have both serious ethical and scientific concerns with Dr. He’s work. The lack of an unmet medical need, the failure to fully engage the communities of stakeholders, and numerous breaches of community and institutional policies and laws represent major ethics violations,” Harvard University and Broad Institute researcher David Liu said in an email interview. “The disturbing lack of correspondence between the DNA sequencing data and the claimed genotypes of the babies, the somewhat superficial off-target analysis, and the lack of characterization of the consequences of the edited forms of CCR5 in these babies raise additional scientific questions that are deeply troubling.”