While working on the revision of a paper on GDPR & open access, I found an interesting table who is fighting whom in science.
| Country | Consortia | Dispute |
|---|---|---|
| The Netherlands | VSNU | Royal Society of Chemistry |
| Germany | Deal | Elsevier |
| Sweden | Bibsam | Elsevier |
| France | Couperin | Springer Nature |
Do we need any of these publishers? I would say no.
What’s currently allowed is in the Sherpa/Romeo list.
Daily Mail reports a study in Human Evolution with comments at phys.org
A scientific study has prompted speculation that all modern humans could have descended from a solitary pair who lived 100,000 to 200,000 years ago.
Scientists surveyed the genetic ‘bar codes’ of five million animals – including humans – from 100,000 different species and the results have prompted speculation that we sprang from a single pair of adults after a catastrophic event almost wiped out the human race.
These bar codes, or snippets of DNA that reside outside the nuclei of living cells, suggest that it’s not just people who could have come from a single pair of beings, but nine out of every 10 animal species, too.
I have heard that before.
While scanning the internet for the crispr’d babies I found some bizarre accounts. One of these is “Revolutionary Phenotype” by Jean-Francois Gariépy, a book to appear in late 2018, and more fi than sci.
Suppose you want to have a child, but instead of reproducing in the traditional fashion, you and your mate opt to store your genetic information on a computer. Then, while your genes are digitally stored on the computer’s hard drive, you decide to make a few minor edits-just some slight improvements to ensure your kid will be healthy. You then dump your revised digital genome into a series of DNA molecules, which you inject into a human egg that has been stripped of its own native genome. Nine months later, your flesh- and-blood child is born, and you and your family proceed with your deeply satisfying life. You end up never regretting the decision you have made to modify a few genes in your child’s DNA. Your child likes it too since he has better health and strength compared to most of his peers. He’s already dreaming of having his own genetically- modified children.
Humans are not only determined by their genome. And the human genome is a bit more than a digital sequence. But maybe this misunderstanding is intended to increase sales.
I never had problems to understand environmental induced sperm methylation as spermatozoa of animals are produced continuously by meiotic division. But I learned that in humans all ova are produced before birth, so how could these ever be influenced by an environmental exposure? It seems that the dogma of prefabricated eggs is wrong as described already in 2012.
Rare mitotically active cells have a gene expression profile that is consistent with primitive germ cells. Once established in vitro, these cells can be expanded for months and can spontaneously generate 35- to 50-μm oocytes
So there is a lifelong chance that environmental exposures both in fathers and mothers can be transmitted to the offspring “fat eggs, fat offspring” – there is no Weismann Barrier. (This remains also an important question as somatic gegen therapy could accidentally introduced germline changes – at least in theory).
But how does any soma to germline transfer work? A new paper examined this in more detail. They found that the negative regulator of sperm activation in C elegans, SWM-1, is produced in body wall muscle, then secreted into the body cavity. Whenever it enters the gonad it finds it target TRY-5, a spermiogenesis activator, that influences sperm success.
So to the more conventional soma to germline theories of persistent methylation changes or RNA fragments ( as described in a recent review) there maybe more possibilities like microbiome transfer.
According to chess24.com
Magnus Carlsen demolished Fabiano Caruana 3:0 in rapid tiebreaks on Wednesday to retain his World Championship title for another two years. He was defiant afterwards about his decision not to play on in Game 12, saying Garry Kasparov and Vladimir Kramnik were, "entitled to their stupid opinions", while he explained, "one of the things I've never done very well is listen to other people's advice. I've always gone my own way... and it's brought me this trophy today!"
In erster Linie bleiben die spinnerten Menschen im Gedächtnis haften, vermutlich weil sie jene Welt verkörpern, die allein mit der Kraft des Verstandes nicht zu durchdringen ist (Hans Kratzer)
… is the pitch drop experiment.
Click to see the drop falling in 14 years or so
This short script is quite useful for DSGVO complaint, aeh compliant websites. Just put a grey picture in /images/externalcontent.png or wherever you want
and insert a short script in the wordpress header.
function showyou() {
$('iframe[name*=".com"]').each(function(e) {
var src=$(this).attr('name');
$(this).attr('src',src);
$(this).show();
});
}
$(document).ready(function(){
$('iframe[src*=".com"]').each(function(e) {
var src=$(this).attr('src');
$(this).attr('name',src );
$(this).attr('src','');
$(this).after('<img class="me" src="/images/externalcontent.png" onclick="$(\'.me\').hide();showyou();"/>
');
$(this).hide();
});
});
This content has restricted access, please email me for the password.
Zu dem Thema äussert sich auf S.21 die Empfehlung des Wissenschaftsrats 2018 zur Hochschulgovernance
Ein weiteres Merkmal von Hochschulen, welches zu Konflikten führen kann, ist die Beziehung zwischen der individuellen und der korporativen Wissenschaftsfreiheit. Damit die einzelnen Wissenschaftlerinnen und Wissenschaftler ihre Freiheitsrechte wahrnehmen können, sind sie auf einen organisatorischen Rahmen angewiesen, der die Ressourcenverteilung vornimmt, arbeitsteilige Prozesse in Lehre und Forschung organisiert, administrative Unterstützung leistet und die erforderlichen Infrastrukturen bereitstellt […] Eingriffe der Hochschulen in die individuelle Wissenschaftsfreiheit ihrer Mitglieder sind von der Verfassungsrechtsprechung ausdrücklich gebilligt worden. Sie "können insbesondere durch das Ziel der […] Erhaltung und Förderung der Funktionsfähigkeit der Hochschulen sowie des Schutzes anderer Grundrechtsträger gerechtfertigt sein". Um jedoch zugleich die Trägerinnen und Träger der Wissenschaftsfreiheit in die Lage zu versetzen, ihre individuellen Autonomieansprüche wirksam zu vertreten, werden sie […] an vielen Entscheidungen direkt beteiligt. Das Bundesverfassungsgericht hat dem Gesetzgeber für die genaue Ausgestaltung der Mitwirkungs- und Kontrollrechte der Wissenschaftlerinnen und Wissenschaftler einen weiten Gestaltungsspielraum eröffnet […]
Das ist eindeutig formuliert.
Vom 12. bis 13. November 2018 fand in der Dialogreihe "Innovation und Verantwortung" eine gemeinsame Veranstaltung “Digitalisierung und Arbeitswelt” statt, die gemeinsam von TTN, acatech und evangelische Akademie Tutzing organisiert wurde.
Für TTN übernahm Stephan Schleissing, für die acatech Marc-Denis Weitze die Moderation.
Digitalisierung - Revolution oder Gestaltungsauftrag?
Prof. Dr. Klaus Kornwachs, Büro für Kultur und Technik, ehem. Lehrstuhl für Technikphilosophie, Brandenburgische Technische Universität Cottbus
Mit Digitalisierung den kulturellen Wandel im Unternehmen gestalten.
Jan Pfeifer, Detecon International GmbH
Ironie der Digitalisierung: Weswegen Steuerungsphantasien zu kurz greifen.
Prof. Dr. Stefan Kühl, Professur für Organisationssoziologie, Universität Bielefeld und Finn- Rasmus Bull, Metaplan
Digitalisierung, Bildung und die Arbeitswelt: Politische Herausforderungen im Gespräch mit Annette Karl, MdL
Arbeit in der digitalen Transformation.
Prof. Dr.-Ing. Dieter Spath, Präsident acatech
Verantwortung in der digitalen Transformation.
Prof. Dr. Peter Dabrock, Lehrstuhl für Systematische Theologie (Ethik), Universität Erlangen- Nürnberg
Annals of Internal Medicine has a disturbing article from a sample of US sample of 522 American Statistical Association members.
The 4 most frequently reported inappropriate requests … by at least 20% of the respondents were …
* removing or altering some data records to better support the research hypothesis
* interpreting the statistical findings on the basis of expectation, not actual results
* not reporting the presence of key missing data that might bias the results
* and ignoring violations of assumptions that would change results from positive to negative.